About the seminar:

Biological research is currently undergoing a paradigm shift from bulk analysis to single-cell analysis, with the importance of cell heterogeneity and individual cell tracing being increasingly recognised.

In this presentation, I shall delve into the cutting-edge developments in single-cell technologies and their applications across a diverse range of fields, including developmental biology, oncology, cardiovascular disease, and ageing. Technology highlights include single-cell Whole Genome Sequencing (scWGS) and sub-cellular spatial transcriptomics such as Stereo-seq . By employing primary template-directed amplification (PTA) for whole genome amplification, scWGS can achieve unparalleled coverage and uniformity in single-cell genome sequencing. Meanwhile, Stereo-seq emerges as the state-of-the-art technology for spatial transcriptomics, delivering whole transcriptome mapping at unprecedented subcellular resolution. In addition, I shall also discuss the potential of single-cell multiomics for insights into how genotype and phenotype correlate at the single-cell level, where phenotype could be defined as gene expression, protein, or even spatial distribution.

Date: Wednesday 10th April 2024
Time: Starting from 2PM
Venue: Seminar Room (building 66)                                                           Center for Molecular Medicine Cologne                                         Robert-Koch-Straße 21, 50931 Lindenthal, Germany